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All of the active B12 group reporting showed reduction in severity of symptoms ranging from 31% to 70%, while the placebo controls reported either no change or a worsening of symptoms. Wilcoxon-Rank of .002 for the end-points of sneezing, nasal congestion and runny nose; and p = .005 for IgE reductions. In 1992, the above mentioned data from 1988 on were presented by Dr. O''Connor to the FDA. The FDA panel acknowledged the safety of the treatment. The panel seemed to be in agreement that the statistics indicated a significant reduction in IgE and that a quantitative drop in symptoms was demonstrated. In 1992, Belen Anibarro, MD, studied five children with asthma with metabisulfite intolerance confirmed by oral challenge testing. The test was repeated after premedication with 1.5 mg of oral cyanocobalamin. In four of the five patients treated, bronchospasm did not develop in the second metabisulfite challenge.6

Feeling fine in general, allergy symptoms improved. C. T. Have been doing a lot better. Lisa L. So far, so good. Andy G. Felt congested, but improved. Richard R. Feeling fine. No problems. Roland H. Feel OK as far as allergies. Angel P. I felt relief after the treatment, and still feeling better. A. V. I feel OK, but have a little congestion. Carlin R. Feel better childrensvitamins than before. Art P. Feel good - continue with sinusitis Bob M. Feeling moderate. Gustavo M. Much better. Alejandro M. What Patients Said After More Than Two Months All my symptoms seem to have gone. Margareth Z. For the first time after taking the treatment, I felt like my life was my own. After 20 years I was able to go out in traffic and high winds with little or no bad effects. I could even tolerate gas lawn mowers. I was able to walk around without huffing and puffing. Pain in throat and lungs disappeared. Getting air in lungs.

Patients gave blood serum samples prior to the treatment in 1992 and one year later in 1993. They were immunoassayed for specific IgE antibodies using a chemi-luminescent technique. Statistician Bradley Rosebrook ran T-Tests comparing average baseline IgE levels to one-year. For the seasonal allergens reported, the active group (n=34) had on average a greater reduction in IgE than the placebo group (n=33).7 On August 14, 1996 representatives of Broncorp, Inc. met with the Division Director, Dr. John Jenkins, and 14 other FDA officials of the Pulmonary Division at a PreNDA meeting. Dr. Mansfield made a presentation on the 1995 study data (n=165) from Oregon, Washington and Idaho. He noted that together the data failed to show statistical superiority of vitamin B12 on the primary endpoint. He noted that in Washington and Idaho, during the later part of the study, there was a drop in the pollen counts and marked improvements in symptoms in both the vitamin B12 and placebo groups. (This made a therapeutic benefit of the B12 treatment difficult to demonstrate.) But that the pollen counts in Oregon remained childrensvitamins higher throughout the study and that the data from Oregon showed a significant difference between the active and placebo groups.8

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